Technically yes, but there's a couple of very easy ways to work around that. The first is to just use a keyboard launcher like dmenu. I use rofi personally, invoked with Super+Space, and have it configured to be able to launch programs and switch to open windows. The other option, which I've also done, is to use a little program called menumaker that will automatically configure your menu for you. It's not in a lot of repos, but it's very easy to find and install. I'd recommend doing both, as I did, just for the sake of convenience.
As far as general config stuff, It's not the easiest to setup (I actually think fluxbox is a bit more simple iirc), but it's not bad. Plus there's utilities like obconf and obmenu that make things easier. And remember that openbox uses a seperate autostart file rather than placing it at the bottom of the config or something.